During the seminar we will discuss full scale flexibility of automative peptide synthesizers from CEM. We will present how to create peptide libraries for different screening projects: epitope mapping, receptor-ligand interactions, substitutional and lengh analysis. We will also present new peptide purification system, which will simplify and speed up the purification process of hydrophobic and long peptides, proteins. In the end we will learn how to use new green solvents for SPPS.